Figure 8

The SARS CoV-2 spike domain, RGD and integrin binding effect-relationship for vaccine design strategy

Luisetto M*, Tarro G, Khaled Edbey, Almukthar N, Cabianca L, Mashori GR, Yesvi AR and Latyschev OY

Published: 20 July, 2021 | Volume 5 - Issue 1 | Pages: 027-041

apb-aid1014-g018

Figure 8:

Coronavirus S protein-mediated membrane fusion- model. A hypothetical depiction of the native prefusion S- protein (left) is depicted binding to cellular CEACAM- receptors. S1 subunit dissociation and S2 unfolding generates pre hairpin- structures (middle) depicted with cell membrane-intercalated FPs and exposed heptad repeat regions (HR1 and -2). Prehairpin closure through a lipid stalk intermediate generates a highly -stable, rodlike 6-HB, in which HR2- helices are positioned antiparallel to an interior HR1 trimer. Palmitates are shown extending from endo-domain- cysteines (C).

Read Full Article HTML DOI: 10.29328/journal.apb.1001014 Cite this Article Read Full Article PDF

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