Figure 2

The SARS CoV-2 spike domain, RGD and integrin binding effect-relationship for vaccine design strategy

Luisetto M*, Tarro G, Khaled Edbey, Almukthar N, Cabianca L, Mashori GR, Yesvi AR and Latyschev OY

Published: 20 July, 2021 | Volume 5 - Issue 1 | Pages: 027-041

apb-aid1014-g002

Figure 2:

Domain- structure of the SARS-S and the SARS-2-S. (A) Key -domains in SARS-S and SARS-2-S. SP, signal peptide; NTD, N-terminal domain; RBD, receptor-binding- domain; FP, fusion peptide; IFP, internal -fusion peptide; HR, heptad repeats; TM, transmembrane- domain; CT, cytoplasmic- tail. The top and bottom numbers in each domain pertain to SARS-S and SARS-2-S, in respectively way. The red- arrows indicate cleavage sites, and their numbers pertain to SARS-2-S; (B) Alignment of SP between SARS-S (top) and SARS-2-S ( see bottom); (C,D) Alignment of 2 inter-domain segments; (E) HR1 in SARS-S and SARS-2-S, together with the top view of a helix showing hydro-phobic- positions a and d on the same side; (F) Hydrophobicity plot generated from DAMBE.

Read Full Article HTML DOI: 10.29328/journal.apb.1001014 Cite this Article Read Full Article PDF

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