Figure 4

The SARS CoV-2 spike domain, RGD and integrin binding effect-relationship for vaccine design strategy

Luisetto M*, Tarro G, Khaled Edbey, Almukthar N, Cabianca L, Mashori GR, Yesvi AR and Latyschev OY

Published: 20 July, 2021 | Volume 5 - Issue 1 | Pages: 027-041

apb-aid1014-g014

Figure 4:

Roles of platelets in thrombosis - hemostasis. After vascular injury, plasma- fibronectin quickly deposits onto the injured vessel- wall. Platelets may also release their internalized plasma -fibronectin from their granules. These plasma and platelet sources of fibronectin likely synergistically contribute to the protein- wave of hemostasis. Platelet adhesion - aggregation ( the classical first wave of hemostasis) are then initiated via platelet- receptors and their ligands. Activated -platelets also provide a negatively -charge surface and mediate cell-based thrombin generation, which contributes to blood coagulation that is initiated following tissue- damage ( the second wave of hemostasis). In a growing hemostatic plug/thrombus, the fibrin and fibronectin- matrix is usually formed in the interface between the injured vessel wall and platelet- plug.

Read Full Article HTML DOI: 10.29328/journal.apb.1001014 Cite this Article Read Full Article PDF

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